![]() ![]() However, the absolute risk of severe complications is low and needs to be assessed against the increased risks associated with SARS-CoV-2 infection if unvaccinated 15, 16. There is also evidence of a range of other rare neurological complications 14. ![]() Previous studies have shown an increase in the risk of myocarditis and myopericarditis associated with mRNA vaccines including BNT162b2 (Pfizer-BioNTech) and mRNA-1273 (Moderna) 8, 11, and an increased risk of thrombotic and other rare cardiovascular events after the ChAdOx1 nCoV-19 vaccine (Oxford-AstraZeneca) 12, 13. There have been rare cases of serious adverse events reported with the COVID-19 vaccines. However, it is also important to consider their safety, which can be difficult to assess in randomised clinical trials that are not powered to detect rare adverse events 2, 3, 10. While the randomised clinical trials focused on short-term efficacy against symptomatic infection, which was subsequently found to wane and be escaped by SARS-CoV-2 variants 2– 7, real-world evidence has indicated stronger and more sustained effectiveness against severe disease and death due to COVID-19 6, 8, 9. On the 8 December 2020, the United Kingdom (UK) began administering vaccines against COVID-19 according to the priority groups determined by the Joint Committee on Vaccination and Immunisation (JCVI) 1. All statistical data used in this study are available from the Office for National Statistics website.Ĭode used in this study is available on Github 41. Hospital Episode Statistics data is not available through the ONS this data is held by NHS England. Microdata on death and vaccination may also be accessed through the NHS-Digital Data Access Request Service. ![]() Details of the application requirements and process, and the use of data, are available at /aboutus/whatwedo/statistics/requestingstatistics/secureresearchservice. Access to the SRS is available to accredited researchers. Test and Trace data (unlinked) is also available through the SRS but is not currently linked to deaths registration data in the SRS. The ONS is working to make death registration data linked to vaccination data from the National Immunisation Management Service available on the ONS Secure Research Service (SRS). The source data used in this study is subject to controlled access due to its sensitive nature. ![]()
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